The executive leadership of ICER consists of a President (Steve Pearson) and a senior management team.  Work is conducted in collaboration with various academic institutions and research organizations based on expertise with a particular topic and/or therapeutic area.  A founding Advisory Board has been created to provide strategic guidance to the Institute.  Board members are comprised of representatives from the Institutions providing ICER with financial and operational support, as well as at-large representatives from key clinical, policy, and advocacy stakeholder organizations.

The work program for ICER is developed with guidance from a multi-stakeholder Topic Selection Committee.  ICER seeks to produce appraisals on topics of importance to all stakeholders, and for which its distinctive methods will help decision makers facing important uncertainties about the evidence on clinical effectiveness and value.