The Institute for Clinical and Economic Review (ICER), based at the Institute for Technology Assessment at Massachusetts General Hospital, provides independent evaluation of the clinical effectiveness and comparative value of health care interventions.  There are several features of ICER’s focus and methodology that distinguish it from other comparative effectiveness assessment organizations.  First, ICER engages more deeply throughout the assessment process with all stakeholders, including patients, clinicians, manufacturers, purchasers, and payers.  ICER also includes as part of all its assessments the results of cost-effectiveness analysis, and continues to work with stakeholders to refine a rating system for comparative clinical effectiveness and comparative value to guide health care decisions.  Lastly, ICER works with all stakeholders to develop and evaluate applications of evidence to create innovative patient-clinician decision support tools, insurance benefit designs, and coverage and payment policies.  Through these activities ICER seeks to achieve its ultimate mission of informing public policy and spurring innovation in the use of evidence to improve the value of health care for all.